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The negative consequences of being involved in Substance abuse can be seen in any emergency department of drug rehabilitation centers and hospitals. These patients often seem to have lost their minds and the health seems in disastrous condition. Findrxonline on his blog suggests that This happens as addiction has the capacity to change a patient's judgment, perception and even physical control. Some of the effects caused due to substance abuse may include problem in the working of different organ system which can eventually lead to multi-system failure, resulting in coma. A lot many people have lost their lives for indulging in such ill habits.