How to patch games in your D drive?

So games like Oblivion and bully have glitches that prevent me from playing the game....like it freezes COMPLETELY due to glitches made by the company. but since the computer is custom made my C drive ended up having 20 gigs used up for basic stuff, and my D drive has about 1000 gigs. so when i go to patch my games i'm automatically refused the chance to patch to the D drive, and it says "sorry, not enough space" or some BS like that. is there a way to patch my games in my D drive?